EuroMAbNet: European Monoclonal Antibodies Network

PDL-1 mouse specific Antibody

Protein information

Plays a critical role in induction and maintenance of immune tolerance to self. As a ligand for the inhibitory receptor PDCD1/PD-1, modulates the activation threshold of T-cells and limits T-cell effector response. The PDCD1-mediated inhibitory pathway is exploited by tumors to attenuate anti-tumor immunity and escape destruction by the immune system, thereby facilitating tumor survival. The interaction with PDCD1/PD-1 inhibits cytotoxic T lymphocytes (CTLs) effector function.

Protein link information

Validation / characterisation

• Working
• No conclusive
• Not working
• Not tested

• CLONE NAME
• APPLICATIONS

Applications legend

• WB: Western blotting
• ICC: Immunocytochemistry
• IHC-P: Immunohistochemistry - Paraffin
• IF-F: Immunoflourescence - Frozen
• IF-P: Immunoflourescence - Paraffin
• FLOW: Flow cytometry
• IHC-P Species: Immunohistochemistry - Paraffin Species