mAbs Against HUMAN Protein
Leu1
| STATUS: | |
|---|---|
| CONTACT INFORMATION: | University of Oxford marketed by Ximbio.com |
| TYPE: | mouse anti human |
| CLONE NAME: | Y2/178 |
| PROTEIN: | Leu1 (CD5) |
| PROTEIN WEB: | https://www.omim.org/entry/153340 |
| ANTIGEN USED: | Normal lymphocytes treated with PHA (phytohaemagglutinin) |
| FUSION PARTNER: | P3/NS1/1-Ag4.1 |
| ISOTYPE: | IgG1 |
| SPECIES REACTIVITY: | Human |
| PREPARATION AND STORAGE: | Aliquot and store at 4C. Do not freeze |
| COMMERCIALIZED BY: | Ximbio.com |
| APP RECOMMENDED: | FACS IHC IF IP WB |
Description
CD5 is a surface glycoprotein present on peripheral T cells (>95%) and B-cell chronic lymphocytic leukaemia cells that binds CD72. CD5 has utility for the monitoring of T-cell numbers in peripheral blood and the identification of leukaemias of T cell origin. Absence of the CD5 marker on childhood ALL cells is associated with a more favourable prognosis.
References
Mol Cell Biol. 2006 Sep;26(17):6727-38.
CD6 regulates T-cell responses through activation-dependent recruitment of the positive regulator SLP-76.
Hassan NJ1, Simmonds SJ, Clarkson NG, Hanrahan S, Puklavec MJ, Bomb M, Barclay AN, Brown MH.
PMID: 16914752
https://www.ncbi.nlm.nih.gov/pubmed/16914752