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Members

Pierre Cosson

Name of the laboratory

Geneva Antibody Facility
Geneva Faculty of Medicine
Centre Médical Universitaire
Rue Michel Servet 1
1260 Geneva 4, Switzerland

Members of the laboratory

Academic supervisor
Unit Leader
Philippe Hammel Pilippe.Hammel@unige.ch
Scientist
Technician
Merina Dhungana Merina.Dhungana@unige.ch

Laboratory activity

Recombinant antibodies are valuable reagents to achieve reproducible experiments. Use of recombinant antibodies also participates in decreasing the use of animals in research. Our aim is to facilitate access of the scientific community to these high-quality reagents. We are involved in all the facets of this new technology: discovery of new recombinant antibodies, production of existing antibodies, characterization of recombinant antibodies, listing all existing recombinant antibodies in a unique database.

Research activities

Discovery of new recombinant antibodies: The Geneva Antibody Facility performs discovery of new recombinant antibodies against defined various targets (proteins, small chemicals). We are also happy to make discovery tools (including phage display libraries) available to all interested parties. The facility can be contacted directly: antibodies@unige.ch

Production of recombinant antibodies: A spin-off company of the University of Geneva (ABCD Antibodies SA) is dedicated to the production and distribution of recombinant antibodies: https://abcd-antibodies.com

Characterization of recombinant antibodies: Antibody Reports is an open-access scientific journal dedicated to the characterization of recombinant antibodies. It is hosted by the University of Geneva: https://oap.unige.ch/journals/abrep

The ABCD database of recombinant antibodies: The ABCD database lists all recombinant antibodies discovered with a known antigen. It currently includes >28’500 antibodies in https://oap.unige.ch/journals/abrep

Techniques available

  • Discovery of recombinant antibodies by phage display
  • Production of recombinant antibodies
  • Phage display libraries
  • Sequencing of hybridomas

Publications (2019-present)

  • Martínez Bedoya D, Marinari E, Davanture S, Castillo Cantero L, Erraiss S, Dockerill M, Barluenga S, Winssinger N, Schaller K, Bijlenga P, Momjian S, Voize C, Tissot SR, Kandalaft LE, Hammel P, Cosson P, Walker PR, Dutoit V, Migliorini D. 2024. PTPRZ1-targeting RNA CAR T cells exert antigen-specific and bystander antitumor activity in glioblastoma. Cancer Immunol Res. In press.
  • Marchetti A, Lima WC, Hammel P, Cosson P. 2023. A quantitative comparison of antibodies against epitope tags for immunofluorescence detection. FEBS Open Bio. 13:2239-2245.
  • Groff K, Allen D, Fiebig M, Cosson P, Casey W, Clippinger AJ. 2022. An approach to identifying quality research antibodies. Biotechniques 73:167-70.
  • Crespo-Yanez, X, Ayadi, I. 2021. The AE889 and AI500 antibodies recognize Klebsiella pneumoniae surface antigens by flow cytometry. Antibody Rep. 4:e570.
  • Lima W.C., Gasteiger E., Marcatili, P., Duek, P., Bairoch, A., Cosson P. 2020. The ABCD database: a repository for chemically defined antibodies. Nucleic Acids Res. 48:D261-4
  • Lima, W.C., Hammel, P., Cosson, P. 2020. A recombinant antibody toolbox for Dictyostelium discoideum. BMC Res Notes. 13:206
  • Hammel, P., Marchetti, A., Lima, W.C., Lau, K., Pojer, F., Hacker, D., Cosson, P. 2020. AI334 and AQ806 antibodies recognize the spike S protein from SARS-CoV-2 by ELISA. Antibody Rep. 3:e186.